If you are an estimator and use Microsoft Spreadsheet for handling your data then QuickMeasure Onscreen is the one TakeOff Software which can be really helpful. The software is highly recommendable for companies that currently manage their estimating in Excel but do not have a formal takeoff system. The system easily integrates with Excel. It is a viable program for most construction segments that deal with generating takeoffs from blueprints. You can can get features like digital takeoff, digitizer integration, CAD file integration and 2D takeoff included in it.
It is completely free for now so, trying once is not a bad option. Watch out the video for better understand about the software
Downlaod QuickMeasure Takeoff Software here: http://download.cnet.com/